‘Saturday Night Live’ To Air Show, Observe Social Distancing

first_imgPhoto: NBCLOS ANGELES — “Saturday Night Live” will be back on the air this weekend with a show that abides by social distancing rules.The comedy sketch show will include a “Weekend Update” news segment and original content from “SNL” cast members, NBC said Thursday.The material will be produced remotely, the network said, in compliance with efforts to limit the spread of the coronavirus. Part of the pandemic’s fallout was a shutdown of movie and TV production that included “Saturday Night Live.” Its last original episode aired March 7.“SNL” is known for its guest hosts and musical artists, but NBC didn’t immediately address whether anyone outside the show’s cast would be be part of this Saturday’s episode, which will air at 11:30 p.m. EDT. “Saturday Night Live” suffered a blow this week with the death of veteran producer and music supervisor Hal Willner. He had not been diagnosed with COVID-19, but his symptoms were consistent with those caused by the coronavirus. Share:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to email this to a friend (Opens in new window)last_img read more

Alzheimer’s: 5 Greatest Risk Factors

first_img Share 12 Views   no discussions Share Tweet Sharing is caring!center_img HealthLifestyle Alzheimer’s: 5 Greatest Risk Factors by: – February 27, 2012 Share Alzheimer’s disease begins at the synapse, the space where neurons connect. The biggest bad guy in this disease is a sticky protein called beta-amyloid. Either too much is made or not enough is cleared away, and as beta-amyloid accumulates, it creates a gooey clog in the synapse, preventing the neurons that meet there from communicating. As a result, the information those neurons carry can’t be transmitted or retrieved. The beta-amyloid “goo” prevents these two neurons from “talking” to each other. We notice this molecular event because we forget something.When too much beta-amyloid causes the synapse to fail, we begin to see the symptoms of Alzheimer’s. There are many risk factors that can contribute to having too much beta-amyloid. What are these risk factors?First, let’s imagine a seesaw-style scale and the risk factors, which each vary in weight, are being piled on one arm of the scale. When that arm hits the floor, we have Alzheimer’s. Risk Factors1. AgeThe biggest risk factor for developing Alzheimer’s is age. For reasons we still don’t entirely understand, as we get older, we accumulate more beta-amyloid. The chances of being diagnosed with Alzheimer’s increase steadily as we age. Right now, the risk of Alzheimer’s doubles every year after the age of 65. About half of people who are 85 and older have Alzheimer’s.2. GeneticsAnother risk factor is genetics. There is a rare form of Alzheimer’s called Familial Alzheimer’s, which always begins well before the age of 65 (typically in the 40s and 50s) and runs in families, that is autosomal dominant. This means that a single genetic mutation causes the disease. Picture the seesaw scale again. Genetic mutation is the only risk factor on the scale, and the arm is sitting on the floor.Scientists have discovered three genetic mutations that cause this early-onset Familial Alzheimer’s. All three of these mutations result in molecular changes that cause an excess of beta-amyloid.But this type of genetic risk factor is relatively rare, accounting for only about 5% of Alzheimer’s cases. The contribution of genetic risk factors to the development of Alzheimer’s for the vast majority of cases weighs much less on the scale, tipping the arm only a little bit.For example, ApoE4 is a known genetic risk factor for Alzheimer’s. Forty to 65% of people with Alzheimer’s carry at least one copy of this mutation. But you can have two copies of this mutation (one inherited from each parent) and not have the disease. Again, imagine the arm of the scale tipped a bit with each copy of this mutation, but the arm is still well above the floor. Likewise, you can have zero copies of ApoE4 but have Alzheimer’s. The arm of your scale would be free of ApoE4 but piled high with other risk factors that tipped the scale over, leading to expression of the disease.3. Head TraumaPrior experience with head trauma, especially if consciousness was lost, increases the risk of developing Alzheimer’s. Always wear a seat belt and helmets.4. DiabetesIn a recent study out of Japan that looked at over 1000 men and women over the age of 60, it was found that people with diabetes (especially type 2) were twice as likely to develop Alzheimer’s. Researchers are now trying to understand the molecular mechanisms that link diabetes to Alzheimer’s. It’s thought that the link may be twofold.Nerve cells require a lot of energy to do the work of communicating. They get this energy from oxygen and glucose in the blood. With diabetes, cells lose their ability to respond to insulin, the molecule that transports glucose from the blood into the neurons, and so neurons have to cope with less glucose. Diabetes also often leads to damaged blood vessels, which compromises the delivery of oxygen to the nerves in the brain. Neurons already struggling to communicate despite too much beta-amyloid may lose the battle if glucose and oxygen are deprived.Think of the scale arm with a bunch of risk factors piled on it. It’s hovering above ground but fighting to maintain that position. Things aren’t looking good for that synapse, but it’s still managing to function. Those neurons are still able to talk to each other. We aren’t showing any symptoms of Alzheimer’s yet. Add diabetes, and less oxygen and glucose to provide the energy the neurons need, and the scale arm goes crashing to the ground. Now we have Alzheimer’s.5. Cardiovascular DiseaseEighty percent of people with Alzheimer’s disease also have cardiovascular disease. Scientists are trying to better understand the link between heart health and Alzheimer’s disease, but we do know a few things about this relationship.Cholesterol drives the production of beta-amyloid. For a brain that is already struggling to keep beta-amyloid levels in check, high cholesterol can be a risk factor that tips the scale. Doctors prescribe statins for people diagnosed with Alzheimer’s to help keep cholesterol levels down.Again, the neurons in your brain need a lot of oxygen to do their job. If you have high blood pressure and if you have plaques in your blood vessels, your blood vessels are less efficient at delivering this oxygen to your brain. Not enough oxygen can be the weight that tips the Alzheimer’s scale.All the risk factors for heart disease (things like poor diet, lack of exercise) are also risk factors for Alzheimer’s. And this means that things like a healthy, Mediterranean diet (whole grains, red and purple fruits and vegetables, fish, nuts) and exercise may not only protect the heart, they may protect us from Alzheimer’s. In fact, in animal studies, exercise has been shown to clear beta-amyloid better than any pharmaceutical we know of. Think of diet and exercise as weights on the other arm of the scale.There is currently no cure for Alzheimer’s, but understanding these risk factors offers us some good news. While we can’t do anything about getting older or the genes we’ve inherited from our parents, eating smart, keeping cholesterol levels and blood sugar low, exercising, wearing a helmet when bicycling or skiing, and wearing a seat belt in the car are among the things we can do to keep the arm of the Alzheimer’s scale from tipping to the ground. By Lisa Genova, PhD YAHOO Healthlast_img read more

USC looks for momentum against conference foes

first_imgEven with a playoff spot assured, the USC men’s volleyball team isn’t taking the last two games of the regular season lightly.Rather, the No. 6 Trojans know that wins at No. 14 UC San Diego and No. 10 Long Beach State this weekend would give them a huge boost as they head into the postseason. USC beat both teams 3-0 in January.“We’re looking to primarily have good momentum heading into this new season,” USC coach Bill Ferguson said. “I told the guys, ‘How would finishing 5-1 at the end of the season feel instead of 2-4?’ — not to harp on a year that might have happened a year before this one.”Ferguson is referencing last year, when the Trojans finished the season winning only two of their last six games but ended up playing in the national championship match. Despite that, the Trojans are focusing on the present.USC (14-10, 11-9) is playing for the sixth or seventh seed in the eight-team MPSF tournament that starts next weekend. The Trojans can get the sixth seed with a win or a UCLA loss this weekend. But if the Bruins win out and USC loses both its games, it will finish in seventh.Either way, that means the Trojans will have to go on the road to play the first round, and they are using these road games to prepare themselves for that.“We just want to really clean things up and get to the point where we can build momentum for ourselves for the playoffs,” said Murphy Troy, junior and opposite hitter. “We know we’re going to have to go on the road [during the playoffs], and we want to start the playoffs on the right foot. That means ending the regular season on the right foot.”The Trojans had a tougher time than expected last weekend, having to go five sets in a win against Pacific and then losing in three sets to No. 1 Stanford in a game that was closer than the score indicated, was the absence of injured starting junior libero Tri Bourne.Bourne broke his left thumb a week and a half ago in practice and hasn’t played since. Ferguson listed him as day-to-day, and he has slowly been building up his practice time. In his place, Ferguson used junior outside hitter Sean Dennis and senior outside hitter Tyler Stevens, both of whom Ferguson praised as doing a solid job, but the team knows it is missing a key element in Bourne.“Whenever you’re changing the lineup around at all, you got to expect some inconsistencies, and that’s what we experienced this past weekend,” Troy said.Dennis started 17 games for the Trojans last year, and Stevens has three years of experience on the team, so Ferguson knows he has capable players ready to go if Bourne can’t play.“We’re going to wait and see. Tri has been practicing. Tyler and Sean have been practicing and playing outside,” Ferguson said. “We’re prepared for what the situation may be but we just don’t know. We’re going to have to see how the bone heals and how much pain [Bourne] can tolerate.”last_img read more


first_imgFINISH LINES: Bargain $50,000 claim Imperative arrived at Santa Anita yesterday after his second-place finish to Moreno in last Saturday’s $1.5 million Charles Town Classic which earned him about $280,000. “He’s earned close to $2 million since I claimed him,” said trainer George Papaprodromou, who saddled the son of Bernardini to upset Game On Dude in the West Virginia race last year, winning $1 million. “We’re thinking of the Gold Cup (at Santa Anita on closing day, June 28), hopefully,” Papaprodromouo said . . . Trainer Simon Callaghan sat down with Aaron Vercruysse and discussed his first Kentucky Derby contender, Firing Line. To see this video and many more interviews plus recent Derby workout footage, visit Xpressbet’s YouTube page at https://youtu.be/UIV_tK04zec . . .Las Flores Stakes winner Harlington’s Rose, prepping for the $150,000 Spring Fever Stakes at six furlongs on May 23, worked four furlongs Sunday in 48.80. Trainer Steve Knapp called the move “excellent.” . . . Congrats to Joe Talamo and Elizabeth Ellis, who were engaged to be married this past Friday . . . On Monday, May 18, Host Town Arcadia will offer lunch and dinner at The Derby Restaurant, 233 Huntington Drive, Arcadia, for a fundraiser to benefit the Arcadia Host Town Committee supporting the Special Olympics. Call 626 447-2430 for reservations. KENTUCKY DERBY GALA AT SANTA ANITA SATURDAY            Fans can join the biggest Derby party west of Kentucky at Santa Anita next Saturday, an afternoon filled with world-class racing, hat contests, mint juleps and live racing.Festivities include an Infield Beer-fest with live music from Seedless, and a party in the Premium Gallop Out in the Club House East. Fans can purchase a Trackside Package for a prime seat and their first drink in a commemorative cup featuring Santa Anita Derby winner Dortmund, plus all the fun and excitement of racing’s best 3-year-olds in the Kentucky Derby.First post time next Saturday is 11:30 a.m. Gates open at 7:30 a.m. Tickets can be purchased at santaanita.com. O’NEILL ENVISIONS TRIPLE CROWN FOR AMERICAN PHAROAHLava Man is one of the newest members of racing’s Hall of Fame, and at 14, the oldwarrior is still in familiar environs as a valued pony at Doug O’Neill’s barn.A California-bred son of Slew City Slew, Lava Man was claimed during his 3-year-old season for $50,000 and retired with earnings of $5,268,706, most of that for owners STD Racing Stable and partner Jason Wood.Lava Man won seven Grade I races, to date more than any other Cal-bred in history, and 17 of 47 starts. Only Best Pal and 2014 Horse of the Year California Chrome have higher career earnings among Cal-breds.Lava Man won three consecutive runnings of the Hollywood Gold Cup from 2005 through 2007 and back-to-back editions of the Santa Anita Handicap in 2006 and 2007.“It’s unbelievable,” O’Neill said of the honor, which will officially be bestowed Aug. 7at the Fasig-Tipton sales pavilion in Saratoga Springs, N.Y.“Usually, your horse has to die to get in the Hall of Fame, so for him to get in it and still be such a healthy horse that’s still active for us daily and a big part of our team is very humbling and an amazing honor,” O’Neill said.O’Neill, who saddled I’ll Have Another to an upset victory in the 2012 Kentucky Derby and came within hours of running for the Triple Crown until an injury dashed those aspirations, has lofty expectations for this year’s favorite, the Bob Baffert-trained American Pharaoh, who worked five furlongs at Churchill Downs this morning under Martin Garcia in 58.40.It was the fastest of 32 drills at the distance. Pharoah galloped out six furlongs 1:11.40.“You just don’t know how good American Pharoah is,” O’Neill said. “He’s looked like anabsolute machine, and he’s doing it effortlessly. For him to win the Arkansas Derby from off the pace shows a different dimension.“If he stays injury-free, he’s got Triple Crown written all over him.” CAPTIVATING ‘VENEDA’-BEHOLDER MATCH LOOMS IN VANITYWhile the Kentucky Derby next Saturday is on every racing fan’s radar screen, another intriguing match looms a week later on May 9 at Santa Anita: the Grade I, $300,000 Vanity Stakes for older fillies and mares, and a possible showdown between streaking stakes winner Warren’s Veneda and two-time Eclipse Award champion Beholder.Warren’s Veneda, a California-bred daughter of Affirmative trained by Craig Lewis for owner/breeder Benjamin Warren, has won three straight stakes, including the Grade I Santa Margarita on March 14.Beholder, trained by Richard Mandella for B. Wayne Hughes’ Spendthrift Farm LLC, was champion filly at two and three and won her first start of 2015, the restricted Santa Lucia Stakes on April 10 in what perhaps amounted to a paid workout.“If I had my preference, she’s not who I’d choose to run against, a two-time Eclipse Award-winning champion, a great mare,” Lewis said. “We’re up against it.”Warren’s Veneda is scheduled to work five furlongs at Santa Anita this Thursday.While Beholder’s opposition in the Santa Lucia might be considered suspect on class, Lewis wasn’t buying.“They might be,” he said, “but Beholder’s prior record and her bankroll indicate that she’s a top-notch mare, no question. You don’t win $3 million if you’re not the goods, and she’s nine out of 10 on this race track. That’s pretty impressive.“They don’t come much better than her, so it’s going to be a challenge.”Mandella could be motivated by a revenge factor. He couldn’t be blamed for still harboring bitter memories of the 1995 Santa Anita Derby, when Larry the Legend, trained by Lewis, won by a head in a stretch-long drive over the Mandella trained Afternoon Deelites.Twenty years later, Mandella called recollection of the defeat “a nightmare.”center_img PEDROZA ‘FIGHTING’ UPHILL BATTLE ON SATURDAYIf Martin Pedroza pulls off a miraculous double next Saturday, it would surpass his signature six consecutive victories on Breeders’ Cup Day, Oct. 31, 1992, at Oak Tree, and his triumph aboard 50-1 shot Martial Law in the 1989 Santa Anita Handicap.All he has to do is win the Churchill Downs Stakes on Private Zone, then catch a plane to Las Vegas for the welterweight title match at the MGM Grand between Manny Pacquiao and undefeated Floyd Mayweather.Oh, and one more thing. First, he needs a ticket to the fight.“He’s licensed, booked and ready to go,” said Pedroza’s long-time agent, Richie Silverstein, of the trip to Kentucky. “If things break right and the race is early, he could leave Kentucky at 4:20 and be in Vegas by 7, and get to the fight on time. But he needs a ticket.”To that end, ever the loyalist Silverstein offered his cell phone number should anyone scrounge up a ducat: 626-232 9898. HALL OF FAME MEMBER LAVA MAN ONE IN $5 MILLIONSATURDAY IS PARTY TIME FOR DERBY AT SANTA ANITAWARREN‘S VENEDA TO WORK ON THURSDAY FOR VANITYPEDROZA EYES RARE DOUBLE: PRIVATE ZONE, BIG FIGHTlast_img read more

A’s wild walk-off vs Twins gives them chance to clinch playoffs at home

first_imgOAKLAND — Throughout this entire week, A’s manager Bob Melvin has refused to even entertain the idea of potentially clinching a playoff berth at home until the exact day presented itself. That day is here.Stephen Piscotty’s mad dash home to score the game-winning run on a walk-off wild pitch from Trevor Hildenberger in Saturday’s 3-2 victory over the Twins shrunk the A’s magic number to one. The A’s (94-61) can clinch a playoff spot in front of their home fans Sunday with a win against the …last_img read more

Maharashtra government formation: NCP-Congress-Shiv Sena common minimum programme to strive for policy direction

first_img Need for consensusAmong the key issues to be discussed is the distribution of Cabinet and State portfolios and posts in various corporations. “The issue of who will become the Chief Minister is sorted. That post will be with the Sena. But there will be talks about appointments to corporations, the Rajya Sabha and the Legislative Council. We have to reach a broader consensus before going forward,” a senior Congress leader said.The CMP will focus on a broader strategy for the next government. “Distribution of portfolios is certainly an issue being discussed, but we have to decide on policy matters such as farm loan waiver, infrastructure projects, industrial growth and the financial condition of the State. There has to be a road map, and we will chalk out the broader picture,” the Congress leader said.The NCP MLAs held a meeting on Wednesday morning where Mr. Ajit Pawar clarified that his party and the Congress would clear certain points following which talks will be held with the Sena on the CMP.“We are not in a hurry. The Governor has given us six months time,” he said. Sena’s demands unacceptable, BJP not in favour of mid-term polls in Maharashtra: Shah A common minimum programme (CMP) being drafted by the Congress-Nationalist Congress Party (NCP) combine and the Shiv Sena will discuss matters starting from distribution of Ministries to broader policy-based issues, sources say.The programme is, however, likely to skip controversial issues. “The CMP will be about policy direction and will not include every issue in the State today,” said a senior Congress leader working on the draft. The issues such as the Sena’s demand for Bharat Ratna to Veer Savarkar will not be in the CMP as it is the demand of a particular party.The NCP on Wednesday appointed a five-member committee including legislature party leader Ajit Pawar, State president Jayant Patil and Leader of the Opposition in Council Dhananjay Munde to hold discussions with the Congress and the Sena. Congress leaders, including former Chief Minister Ashok Chavan and State president Balasaheb Thorat, met at the office of the former Chief Minister Prithviraj Chavan to identify similarities in the manifestos of the three parties and come to common points to move forward.Sena chief Uddhav Thackeray is directly monitoring the discussions along with senior party leaders.Also Readlast_img read more

Russias romance with Raj Kapoor lives on, 29 yrs after death

first_imgBy Asim KamalMoscow, Aug 13 (PTI) Ranbir Kapoor might be setting hearts aflutter back home in India, but Russia still has just one rockstar Kapoor — and thats his grandfather.More than 29 years after his death, Showman Raj Kapoor continues to rule Russia as the king of the Indian film industry.Generations of Russians — even the young — are aware of Raj Kapoor and his cinema and regard him as Bollywoods numero uno hero despite the new crops of Indian actors who have made a global mark, with their films being released worldwide.”Raj Kapoor for sure still holds the title of the Indian film industrys king here in Russia. He is the number one association we have when we talk about Indian cinema,” said 25-year old Annie Vo.Moscow-born Vo, of Vietnamese origin, stressed he was her “favourite” because of the true to life characters he played.”His characters are very down to earth, true to life and genuine. Anybody can connect to his films, cutting across age, race, education and social status,” she told PTI.The creative director at Bardelhi restaurant, which serves Indian food and frequently screens Hindi films at its special movie nights, said she had heard of Ranbir and seen Barfi!, but it is Raj Kapoors legacy that lingers.”Call me conservative, but I relate more to Rajs era of actors and their level of class,” she said.Raj Kapoor, who passed away aged 63 in June 1988, acted in a series of classics such as Shree 420 and Awara and is still widely known as “the greatest showman of Indian cinema”.advertisementMany in Moscow stressed it was his cinema that introduced Russians to Indian films, which was why he continued to wield such magic.Nozima Karimova, a PR firm employee, recalled the reception the actor was accorded at the Tashkent film festival.”People spoke of his visit like he was higher than any head of state or any celebrity in the world,” she said.Karimova said she knew the Kapoor family was a part of the Indian film world, but was “not certain” about his grandchildren.”For, even today, I watch retro movies of Indian cinema,” she said.Karimova said she often watched Indian films on Russian Zee TV, aired on many cable networks here dubbed in Russian or with subtitles.Vo added that apart from Kapoor, people liked Mithun Chakraborty, Shah Rukh Khan, Aishwarya Rai and Priyanka Chopra.Dilmurad, a Taxi driver in his 50s, said Barood, a 1976 film featuring Rishi Kapoor, and the 1969 Rajesh Khanna- starrer Aradhana were among his favourites.”I went to see Aradhana one morning. I liked it so much that I watched it three times the same day,” he said.Some of the newer releases have their share of viewers, too. Ivan Parfenov, a sports media executive, said he was not a fan of Indian cinema, but was “greatly impressed” by the Rajinikanth-starrer, Robot.”One evening after a few drinks, a few friends and I were at home watching funny videos on YouTube, when a friend put on a clip from Robot. After watching it for 30 seconds I exclaimed that we had to download and watch it,” he said.Leonid Parfenov, creator of a TV and book series called “Namedni”, year-by-year accounts of important developments in culture and everyday lives in Russia, mentions the role of Raj Kapoor in an article on the popularity of Indian cinema.”It all began with Raj Kapoor, the lead actor in Awara and his songs…The rules of the genre never change: immense love, sweet-sounding songs cause charm and tears,” he wrote in a 1976 chapter titled Seeta and Geeta.Talking about the reason Indian films were popular in Russia, Parfenov said, “I often saw women on their way from a film in tears and smiling and saying things like Now this is a film about life.” PTI ASK BDSlast_img read more

Saskatchewans main First Nation organization backs Conservative bill to make band politician

first_imgAPTN National NewsThis week the federal government tabled the First Nations Financial Transparency Act.It would require all First Nations to make public the salaries of their chief and council.It would also make financial statements of their operations accessible to the public.The Federation of Saskatchewan Indians says it welcomes the transparency and accountability it will bring.They hope how, the government will spend their time and energy on addressing important issues like housing, education and safe drinking water.In the past, the FSIN has repeatedly called for a First Nations auditor general’s office.last_img read more

City Council approves rezoning of land for the Anglican Church

first_imgNow that zoning has been put back to its original state the church will sell the property and is looking forward to finding another piece of land in FSJ and building there.To read more about the Anglican Church and the selling of their land CLICK HERE FORT ST. JOHN, B.C. – Council approved the rezoning application for the Anglican Church to return the designation of the land from Institutional to Low-Density Residential.At the public hearing held January 14th, 2019 during the Council Meeting, Council approved the Zoning Amendment for 8907 – 112 Avenue which is the land owned by the Anglican Church.“Two years previous this property had changed its zoning from residential to institutional in order to build a Church on the land. At the time of purchase, no one caught there was a ‘building scheme’ attached to the land, and it could not be removed.” says Bishop Lehmannlast_img read more